The studies behind the grade
guideline recommendation · women; BRCA-related cancer risk
This is a recommendation from the U.S. Preventive Services Task Force, based on its review of the evidence for a defined age and risk group.
meta-analysis of RCTs · 18 RCTs · adults receiving genetic risk information
These figures come from randomized trials, the strongest test of cause and effect. They describe the people who were studied; whether they apply to you is a question for your doctor.
What it costs
- Foundation: Skip or 23andMe · $99 one-time
- Measured: Color Health · ~$250
- Concierge: Clinical-grade genomics (bundled) · Bundled
Costs are the Protocol's cost notes for each tier.
Sources
- U.S. Preventive Services Task Force (2019). BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing. USPSTF. Verified September 2026
- Hollands GJ et al. (2016). The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis. BMJ. Verified September 2026
A grade describes the quality of the research. It is not a treatment recommendation. Talk to your doctor about what's right for you.
Evidence, compared. Not medical advice. Talk to your doctor about what's right for you.
Common questions
- What does the grade mean?
How strong the research is, on the published YL360 Methodology scale. Grade A: the evidence is clear. Grade C: the evidence is thin or mixed. The grade rates the studies, not you.
- Does a higher grade mean a bigger benefit?
No. The grade rates the quality of the evidence. The studies listed show what kind of research it is, how many people were studied, and who they were. A Grade A with a modest effect is common.
- Where do the costs come from?
From the YL360 Protocol's cost note for each tier. Prices on comparison pages carry their own verified dates.
- Is Genetic testing worth it, then?
That depends on your age, your risk and your budget, and it's a conversation with your doctor. This page gives you the evidence and the price so you walk in prepared.
- Is this medical advice?
No. It's evidence, compared. Talk to your doctor about what's right for you.